The material of the drug packaging box used for drug tablets is in direct contact with the drug, so it belongs to a class of drug packaging. Medicine is a special commodity whose efficacy and quality are directly related to people's health and safety. The packaging materials and structural forms used must ensure the efficacy of drugs, and also play a role in ensuring the reliability and convenience of drug use. Therefore, as a pharmaceutical manufacturer, when selecting packaging materials, it is necessary to understand some properties and characteristics of packaging materials and containers, so as to combine some special requirements of drugs, and select pharmaceutical packaging materials reasonably and accurately.

plastic bottle packaging

The biggest feature of medicinal plastic bottles is that they are light in weight, not easy to break, clean and beautiful, and can be used directly by pharmaceutical manufacturers without cleaning and drying. Some of its technical indicators and a large number of data show that its chemical resistance, water vapor permeability resistance and sealing performance are excellent, and it can completely shield and protect the contained drugs within the validity period.

There are high-density polyethylene bottles (HDPE), polypropylene bottles (PP), polycarbonate bottles (PC), and polyester bottles (PET) in the varieties of materials used. In the early 1990s, blow molding bottles were developed abroad. The new material polyethylene naphthalate (PEN) plastic bottle, its properties are better than PET, it has high strength, good heat resistance, UV resistance, excellent barrier properties to carbon dioxide gas and oxygen, chemical resistance Well, it is more widely used than PET. PEN material is a new type of polyester resin actively developed at home and abroad in recent years, and it is also an excellent material for pharmaceutical plastic bottle packaging.

Due to the many specifications of medicinal plastic bottles, small dozens of milliliters, large thousands of milliliters, some colorless, some transparent, various colors, different shapes, and many categories. In the face of the splendid plastic bottle market, as a pharmaceutical manufacturer, the following principles should be grasped when choosing plastic bottles:

1Choose the main raw material and auxiliary formula of plastic bottle

The product standards for solid plastic bottles respectively stipulate the applicable main raw materials, and must meet the requirements of non-toxicity and no peculiar smell. Since there are many kinds of main raw materials available for selection, it is necessary to select the comprehensive properties of the raw materials. Generally, high-density polyethylene and polypropylene bottles are used for tablets. If transparency is required, PET bottles can be used. If medicines need higher barrier properties, light-blocking and opaque, brown PET bottles are used. The better barrier properties are PEN bottles. Liquid dosage forms generally use polypropylene bottles or polyester bottles as the main raw materials.

2 The tightness and water vapor permeability of the bottle body and cap

Airtightness and water vapor permeability are two important technical indicators of medicinal plastic bottles, and they play a crucial role in the stability of the charge.

3 Plastic bottle product quality standards

The quality of the product can be judged from the product quality standard of the manufacturer. Pharmaceutical plastic bottle companies should formulate corporate standards that are stricter than national standards and industry standards.

4 Quality assurance system

Auditing suppliers has become an essential part of purchasing plastic bottles. Through the audit, it is possible to make a comprehensive and correct assessment of the production plant's software and hardware facilities, technical equipment, and comprehensive quality level.

5 Stability and compatibility of charge in plastic bottles

The selection of plastic bottles, especially the selection of new plastic bottles (or new materials and new processes) for new drugs, should firstly conduct a charging test to investigate the stability of the charging and the compatibility between the plastic bottle and the drug. The penetration, dissolution, adsorption, chemical reaction and denaturation of drugs and plastic bottle materials must be determined through scientific testing.